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The Best Supplements to Lower Cholesterol in 2025
Written By Supplement Institute Review Team
Numerous people suffer from high cholesterol levels, with more than 35% of the total adult US population experiencing this health issue. However, with a bit of care and the right supplements, you can have your life back. It’s time to take back control and stop high cholesterol from controlling your life.
We’ve scoured the internet and reviewed the best supplements to lower cholesterol in 2025. We especially like the organic wheatgrass powder from Nutricost because it can lower cholesterol, boost energy, and support the immune system. With help from our reviews and buying guide, you’ll be able to find a supplement that’s best suited for your unique health needs.
The Best Supplements to Lower Cholesterol of 2025
Nutricost Supplement to Lower Cholesterol
Best Overall
Energize your day with the Nutricost organic wheatgrass powder. As a pure and nutrient-packed superfood, this wheatgrass powder is grown organically and harvested at its peak, providing a convenient way to infuse your diet with a wealth of essential vitamins. It also contains plenty of minerals, antioxidants, and chlorophyll known for their cholesterol-lowering effects.
From increased energy levels and detoxification support to an impressive immune system boost, you’ll enjoy the vibrant and verdant essence of this supplement for lowering cholesterol and enhancing your overall health. This product can help you embrace the vitality of nature’s own energy booster in a powerful nutritional supplement, making it our top choice.
Iwi Supplement to Lower Cholesterol
Best Vegan Option
Made from a derivative of algae EPA, Iwi’s Algae Omega-3 + EPA supplements claim to lower your cholesterol and overall VLDL levels by an average of 25% within three months. They also boast a solid lineup of antioxidants, like chlorophyll, phytosterols, omega-7, carotenoids, and more, to back up these claims.
All the ingredients used in producing these supplements for lowering cholesterol are entirely vegan, cruelty-free, and non-GMO certified. Even more, 1% of the total sales goes to Ocean Unite to help them provide more ocean-positive actions. Along with addressing cholesterol levels, these supplements can enhance your immunity, eyesight, and even your skin.
Purely Holistic Supplement to Lower Cholesterol
Best for Heart Health
The Purely Holistic red yeast rice caps are the ideal supplements to lower cholesterol and improve cardiovascular health. It contains 1200mg of red yeast rice, CoQ10, and niacin per serving, providing you with a powerful blend of ingredients that work in synergy to support healthy cholesterol levels in the body.
Red yeast rice contains naturally occurring compounds, specifically monosaccharins, which inhibit the production of cholesterol in the liver. Along with CoQ10, these compounds can be beneficial to maintain healthy cholesterol levels. The rigorous testing and screening process that goes into this product allows it to yield a purer dietary supplement, free of contaminants or impurities such as Citrinin. It’s also non-irradiated and vegetarian-friendly.
Double Wood Supplement to Lower Cholesterol
Best Flavor Profile
Double Wood’s citrus bergamot supplements are made from high-quality citrus bergamot extracts sourced directly from farms in Italy. These fruit extracts are clinically patented and proven to reduce cholesterol levels, all while maintaining them at a healthy level.
Even better, these supplements to lower cholesterol are made from GMO-free, gluten-free extracts and are perfect for those on vegan diets. All of the capsules are also manufactured and tested in the U.S.A. and are patented under the name Bergamonte, making them a truly trustworthy way to lower your cholesterol.
Nature Made Supplement to Lower Cholesterol
Best Unflavored Option
Not all cholesterol in your body is bad cholesterol—a good supplement will ignore the good cholesterol while focusing on reducing the bad, which is precisely what Nature Made’s CholestOff Plus does. Made from a blend of plant-based sterols and stanols, these supplements pay special attention to the reduction in LDL cholesterol.
These supplements to lower cholesterol are clinically proven to help enhance your cholesterol levels. Even the manufacturing process and ingredients have been tested and approved by the USP, the regulatory authority of dietary supplements. The brand has put in years of research, perfecting this supplement to be an excellent way to lower your cholesterol.
Genius Heart Supplements to Lower Cholesterol
Best for Young People
About 7% of the total adolescent population of the US suffers from high cholesterol levels, which is alarming. Thankfully, the Genius Heart & Cardiovascular supplements are here to help to lower cholesterol in young people. Formulated with clinically approved Pantesin Pantethine, these supplements are easy to consume and work on a cellular level to control cholesterol and blood pressure.
Additionally, these supplements to lower cholesterol work as a brain booster, increasing focus and mental clarity along with getting rid of brain fog, allowing kids to get better at studies while protecting their hearts. They also boost the nitric oxide levels in your blood, expanding the vessels and preventing ailments like varicose veins.
Buying Guide: Supplements to Lower Cholesterol
Our health is at the top of our priorities list—everything else should be secondary. This is why it is crucial to take the proper precautions to avoid or lessen the impacts of one of the most common ailments plaguing our society: high cholesterol.
Luckily, supplements to lower cholesterol have been one of the most common and effective ways to control your cholesterol levels. To ensure you get the most value out of your purchase, let us go through everything you need to know before you invest in a bottle of supplements.
Features of Quality Supplements to Lower Cholesterol
Composition
Medicine, regardless of classification, has always been about composition. Something you consume to get better cannot contain anything that might have adverse side effects.
Additionally, many companies use filler content to increase the mass of their supplements. These fillers have no benefit to your body, so ensure that a significant percentage of the composition is made up of good ingredients.
Also, be sure to consult your doctor when deciding on supplements and ensure all the ingredients used in your preferred supplements are either good for you or at least do not cause any harmful side effects.
Ingredients
Some of the most effective cholesterol-controlling components that you need to look for in a supplement are:
- Green tea extract
- Tea tree oil
- Garlic
- Omega-3 fatty acids
- Phytonutrients
- Plant sterols
- Beta-glucans
Vegan-friendly
Many people prefer vegan supplements over synthetic ones because vegan ingredients are derived from organic sources with fewer side effects and are eco-friendly. But, if you are suffering from a severe condition, you may need to depend on fast-acting synthetic medicines because of the quick relief they provide.
Additionally, most vegan pills use plant-based gelatin for soft gels and make sure the ingredients, such as omega-3s, come from non-animal sources. The decision depends upon your situation and urgency, but make sure to always consult your physician before committing to something like a synthetic supplement to lower cholesterol.
Additional benefits
With their primary focus on getting your cholesterol levels in check, many supplements provide additional benefits like blood pressure control, anti-aging, blood sugar control, and brain-boosting.
When looking for a supplement to lower cholesterol, check out any extra benefits you can take advantage of and invest in something that provides you with more holistic healthcare rather than something specific.
Safety certifications
There are a lot of certification authorities working in the U.S. that make sure you do not consume anything that would cause harm to your mind or body. When looking at a supplement to lower cholesterol, it’d be ideal to pick something that has been certified by USP as a clinically tested and approved supplement.
Some of the other certifications that should be sought after are certified GMO-free and cruelty-free. Having certifications like these, along with others, will give you an added layer of safety and confidence when consuming cholesterol-controlling substances.
The Difference Between LDL and HDL
Before you buy supplements to lower cholesterol, you need to know the difference between good and bad cholesterol.
HDL
HDL stands for High-Density Lipoprotein, also known as good cholesterol. This is based on the fact that HDL carries cholesterol directly to your liver. Your liver then processes the cholesterol, removing it from your blood flow and converting it into something beneficial for your body.
LDL
On the other hand, LDL stands for Low-Density Lipoprotein, which signifies bad cholesterol. This is because LDL is taken directly to your arteries, which leads to significant heart problems. LDL cholesterol is the type that’s targeted by supplements that lower cholesterol.
For example, the aforementioned Beta-Glucan, according to Nancy Mitchell RN with Assistedlivingcenter.com, “works by preventing bile from being reabsorbed into the blood from the intestines. In doing so, it reduces the amount of bile available for making cholesterol.”
There are many ways cholesterol supplements help reduce cholesterol. Talk to your doctor about which mechanism and ingredient is best for your particular health needs.
People Also Asked
How long does it take for cholesterol supplements to work?
You should see significant changes in your cholesterol levels within two to four weeks after starting treatment, but the specifics can be found by consulting the provided manual or the label. Additionally, your diet and lifestyle play an essential role in the effectiveness of your supplements.
Do cholesterol supplement treatments require exercising as well?
Although many people take these supplements along with diet changes, exercise can help the body reduce harmful cholesterol levels and increase good cholesterol levels. Exercising and being more physically fit will help your medicines work better, and you'll see results faster.
Are there any side effects in supplements to lower cholesterol?
Yes, sometimes these supplements can cause side effects like fatigue, nausea, heartburn, and low blood pressure. Always have your doctor check the compatibility of your supplements with any existing medications you are taking or if you have any medical conditions before taking them.
What are optimal cholesterol levels?
For adults, according to Johns Hopkins, normal cholesterol levels for adults are less than 200 mg/dL, borderline high is up to 239mg/dL, and high is over 240mg/dL.
How else can I help reduce my cholesterol?
You can help reduce your cholesterol by eating less trans and saturated fats. Instead, try to consume more omega-3s, for example, in fatty fish like salmon.
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