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The Best PQQ Supplements of 2025
Written By Supplement Institute Review Team
Pyrroloquinoline quinone or, PQQ for short, is a natural antioxidant commonly used as a dietary supplement. It offers various health benefits including anti-aging, neuroprotection, cardiovascular health promotion, immune system boosting, cancer prevention, and anti-inflammatory properties. It’s naturally found in certain foods, such as green leafy vegetables and dairy products, but many people opt for supplements for enhanced benefits.
We’ve reviewed the best PQQ supplements of 2025 to help you find the right options for your regimen, starting with the Nutricost capsules. These quality supplements can improve your mental clarity and energy levels while boosting your immune system, earning them the top spot on our list.
The Best PQQ Supplements of 2025
Nutricost PQQ Supplement
Best Overall
Our first pick employs only high-quality PQQ in plant-based capsules, making it straightforward to supplement your diet with PQQ by limiting it to just one capsule each meal. Each serving of the Nutricost PQQ supplement contains a serving of powerful, non-GMO, gluten-free, and high-quality pyrroloquinoline quinone.
To ensure optimal quality and to make you feel your best, Nutricost only employs the greatest ingredients. These supplements are made in a GMP-compliant facility and include high-quality ingredients. Owing to its efficacy, quality manufacturing, and great results, it’s the top pick on our list.
Double Wood PQQ Supplements
Top Energy Optimizer
Our next PQQ supplement from Double Wood functions as a cofactor or enzyme booster in the oxidation-reduction process and provides a huge boost to your mitochondria’s ability to give energy to your cells and support cellular metabolism.
According to research, this PQQ supplement may increase both the number of mitochondria and their efficiency. This increased mitochondrial efficiency benefits energy levels, cognitive function, and sleep quality and may stimulate nerve growth factor (NGF) synthesis, which can help neurons develop and survive. Made and tested in the United States, this pick is non-GMO, gluten-free, and vegan friendly.
Toniiq PQQ Supplements
Most Pure
Each capsule of the Toniiq PQQ supplements contain the highest grade pyrroloquinoline quinone, which has been processed using a method that achieves 99% purity. Every batch is tested for quality and purity both during and after manufacturing, to ensure that you are receiving a good quality product.
Moreover, each batch is analyzed by both the company and an independent third-party laboratory to ensure that the components meet the defined level of purity and active substances. The company obtains its ingredients from the United States, and manufactures the supplement in a GMP-certified and NSF-approved state-of-the-art manufacturing facility to ensure quality results.
Jarrow Formulas PQQ Supplements
Quality Tested
Our next pick from Jarrow Formulas is another top option if you’re looking for a quality PQQ supplement. This company has a mission to promote optimal health through high-quality, effective, affordable, and outstanding dietary supplement formulation; and this capsule is no exception.
Each capsule contains a serving of PGG, an essential antioxidant that stimulates mitochondrial formation while also promoting heart and brain function. You can be assured of the purity, value, and potency of the product thanks to its recurrent testing.
Health Thru Nutrition PQQ Supplements
Best Vegan option
Investing in the Health Thru Nutrition PQQ supplement will play an important role in the growth and development of the mitochondria throughout your body, including the brain. This pick gives you your required daily intake of PQQ in one easy-to-swallow, non-GMO capsule.
With a one-of-a-kind ability to activate cell-signaling pathways involved in cellular energy metabolism, as well as mitochondrial function and development, PQQ-induced spontaneous mitochondrial biogenesis has become critical for human health and longevity. To attain such benefits, investing in this choice is a safe bet.
PQQ Supplements: A Buyer’s Guide
PQQ (pyrroloquinoline quinone) is a natural antioxidant found in fruits and vegetables. It has been studied extensively for its anti-cancer properties, but recently researchers have discovered that it also helps boost energy levels.
PQQ can be taken in supplement form or through food sources such as broccoli, kale, spinach, tomatoes, and red peppers. The recommended dosage varies from person to person, but many experts recommend a PQQ supplement if you are lacking this nutrient in your typical diet.
What is PQQ?
Pyrroloquinoline quinone (PQQ) is a powerful antioxidant found in foods such as broccoli, spinach, kale, brussel sprouts, peppers, eggplant, cauliflower, sweet potatoes, tomatoes, strawberries, cantaloupe, and watermelon. This compound has been shown to help boost energy levels, improve digestion, enhance immunity, fight cancer, reduce inflammation, prevent heart disease, lower cholesterol, and promote overall health.
PQQ supplements are usually 100% natural and can be taken daily without any side effects. They do not contain caffeine, sugar, gluten, lactose, or artificial colors, and they are manufactured under strict quality control standards. They are tested regularly to ensure their safety.
Primary Functions Of PQQ
PQQ is a vitamin-like substance that is widely present in nature and is a powerful antioxidant capable of scavenging free radicals. It helps regulate mitochondrial function, supports nerve growth factor production, and promotes cellular regeneration. These primary functions of PQQ make it a valuable addition to any diet.
- PQQ aids in the formation of mitochondria and thus contributes to their proper functioning. PQQ is also involved in the synthesis of neurotransmitters and neuropeptides that control mood and behavior.
- Nerve growth factor (NGF) is a protein produced by cells to stimulate the growth of neurons. Neurons are responsible for transmitting signals from the central nervous system to the rest of the body. NGF is necessary for the survival and maintenance of neurons throughout the body and some research points out that PQQ supplements aid in the process.
- PQQ is a strong antioxidant due to its ability to scavenge free radicals, since free radicals are highly reactive molecules that damage DNA and cause cell death. Antioxidants neutralize free radicals, preventing them from damaging cells.
- PQQ promotes cellular regeneration, meaning that it helps repair damaged cells before they turn into cancer. PQQ prevents cancerous cells from forming by promoting apoptosis, or programmed cell death.
Advantages of Using PQQ Supplements
In recent years, research has shown that PQQ may have many potential applications including health promotion, maintenance of good health, and disease prevention.
Effect on blood pressure
A study aimed to investigate whether PQQ supplementation could affect blood pressure and heart rate in hypertensive patients. The results suggest that PQQ supplementation may be effective in reducing cardiovascular risk factors in hypertensive subjects.
Fat metabolism
Another study looked at how PQQ affected fat metabolism through a reduction in adipogenic differentiation in the presence of PQQ. They also demonstrated that PQQ regulates intracellular signaling pathways involved in adipogenesis.
Energy production
A third study investigated the effect of PQQ on natural energy production. By looking at the expression levels of genes known to regulate mitochondrial biogenesis, they found that PQQ increased the expression of several genes associated with mitochondrial biogenesis. Together, these data demonstrate that PQQ promotes mitochondrial biogenesis and enhances natural energy production.
While we are just starting to understand the incredible benefits of PQQ, preliminary research indicates that it may help fight oxidative damage in the body, improve cardiovascular health, reduce the risk of cancer, promote weight loss, and enhance memory.
How to Find an Ideal PQQ Supplement
Here’s how to get the right PQQ supplement:
Desired results
Before purchasing any supplement, first, consider what your end goal is. Do you want to improve your current health, prevent future disease symptoms, or simply maintain a general level of wellness? If you have specific goals, then you’ll need to choose a supplement, and its relevant dosage, accordingly.
Consider your dosage
The dosage size of a PQQ supplement should depend on how often you plan to take them and how much you’re currently taking. In either case, start small and work your way up gradually until you reach the desired dose. Consult your doctor for specific dosage instructions.
Choose a quality supplement
If you’re searching for the top PQQ supplements, make sure to check out the ingredients list and read reviews online. Look for a supplement that contains 100% pure PQQ and has no added fillers or other contaminants.
People Also Asked
Which foods have PQQ naturally?
Naturally, PQQ is found in kiwi, papaya, parsley, potatoes, beans, fish, and leafy vegetables, among other things.
What is the right dosage of PQQ per day?
It's important to follow what your doctor has prescribed, as the correct dosage can vary based on a variety of factors.
What are the side effects of PQQ?
A vast range of studies and testing has shown no adverse effects. However, if you sense any side effects, it's important to discontinue the supplement and seek medical help.
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