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The Best NAD Supplements for Naturally-Enhanced Energy
Written By Supplement Institute Review Team
NAD (nicotinamide adenine dinucleotide) is an essential nutrient found in all human body cells. It plays a vital role in cellular energy production, all while improving our energy levels, supporting better focus and mental clarity, and enhancing blood flow. Our bodies don’t produce enough of it naturally, so many people turn to NAD supplements for their benefits.
We reviewed the best NAD supplements of 2025, including the patented option from TRU Niagen. It’s our top pick for the range of benefits it provides, from improved hair health to lowered cholesterol. Find the right supplement for you with help from our reviews and buying guide.
The Best NAD Supplements
TRU Niagen NAD Supplement
Best Overall
TRU Niagen’s multi-award-winning patented NAD supplement offers a safe, effective way to increase your cells’ metabolism and repair them for enhanced vitality and healthy aging. Made in the USA, it’s undergone 22 tests for potency and safety, ensuring it meets the highest quality standards. Most notably, it’s supported by over 300 published scientific studies and two Nobel Prize winners on the research team, as well as 40 owned and licensed patents.
This supplement works by increasing your NAD+ levels, which can help your cells cope with various stressors and maintain their vitality and function. Since this NAD supplement is available in multiple sizes, too, you’ll be able to choose the right amount for your needs. Its thoughtful and effective formulation delivers a range of benefits, from lowered blood pressure to improved mental focus, earning it the top spot on our list.
HPN NAD Supplement
Best for Weight Loss
The HPN NAD Supplement is an anti-aging cell booster that offers the ultimate in cellular health and natural energy. This is largely because it contains an advanced form of NR (nicotinamide riboside), a molecule that helps your cells create more NAD, which is clinically superior to any other on the market. It also has NAD3, a combination of NR and NAD+ boosters that are proven to extend your cells’ lifespan by promoting their repair and regeneration.
Another key ingredient is the NRF2 Activator, which helps activate the NRF2 gene in the body and lets it initiate natural protection against cellular damage caused by free radicals and other environmental factors. Meanwhile, the Nicotinamide Riboside Alternative makes sure that your cells don’t run out of fuel and stay healthy for a long time. Overall, I think it is safe to say that your body is sure to thank you for introducing this NAD supplement to your routine.
Nutricost NAD Supplement
Boosts Overall Wellness
Fuel your body and mind with the Nutricost NAD Supplement, designed to support cellular energy and overall wellness with a powerful dose of Nicotinamide Adenine Dinucleotide (NAD+). Each bottle comes with 120 vegan-friendly capsules, giving you a two-month supply of this essential coenzyme that plays a key role in energy production, cellular repair, and healthy aging.
With 1,000mg of NAD+ per serving, this supplement is ideal for those looking to maintain vitality, focus, and stamina throughout the day. It’s made with non-GMO ingredients, completely gluten-free, and produced in a GMP-compliant, NSF-certified facility, ensuring high-quality standards from start to finish. Whether you’re focused on daily performance or long-term health, Nutricost offers a clean, convenient way to support your energy from the inside out.
Orgabay NAD Supplement
Best Energy Boost
If you’re looking for a NAD+ supplement that delivers maximum benefits, you might want to check out this pick from Orgabay. This product uses liposomal technology to ensure that almost 100% of the NAD+ and TMG (trimethylglycine) in each soft gel reaches your cells to support your energy and methylation cycle.
It stands out to me because, unlike other NAD supplements, this one has a high dose of 500 milligrams of NAD+ and 250 milligrams of TMG per serving. This means it can help boost your cellular health, protect your DNA, promote mitochondrial integrity, and enhance your sleep and mood. Plus, this product is made with natural ingredients, no GMOs, and no soy, so you can trust its quality and safety. Even more, you only need to take one soft gel a day for 60 days to see the difference.
Rossylla NAD Supplement
Best for Cognitive Function
Boost your NAD+ levels and support your cognitive health with the Rossylla NAD supplement, the ultimate choice for your health and wellness. This supplement delivers a whopping 1,300 milligrams of NAD+ per serving, giving you all of the benefits this vital molecule offers. Thanks to the liposomal technology, you can enjoy NAD+ with superior absorption and greater bioavailability, ensuring that it reaches the cells that need it most.
The capsules are also easy to swallow and convenient to take, making this supplement a breeze to add to your daily routine. Most importantly for me — especially when it comes to something you’re putting in your body — you can trust that these NAD supplements are made with the highest quality ingredients, backed by science along with thousands of satisfied customers. Rest assured that you’re getting a safe, reliable product that will help you achieve your health and wellness goals.
Buying Guide: NAD Supplements
NAD, or nicotinamide adenine dinucleotide, is a vital molecule that helps your cells produce energy and perform various functions. But as you get on in years, your NAD levels go down, and that can make you feel tired, foggy, inflamed, and old. That’s why many people take NAD supplements to boost their NAD levels and improve their health and wellness.
But how do you choose the right supplement? There are so many options out there, with different names, forms, doses, and qualities, so deciding can be confusing and overwhelming. Don’t worry, we’ve got your back. In this guide, we’ll help you understand the key features of NAD supplements and how to compare them, all while providing some tips on how to use them safely and effectively. By the time you finish reading this guide, you’ll be ready to pick the best NAD supplement for your needs.
What to Consider When Buying NAD Supplements
Quality
Quality and transparency are key factors when choosing NAD supplements. You want a product that comes from a trustworthy manufacturer who cares about its process and its customers. That includes using quality ingredients, providing dosage instructions, clearly showing the ingredients and their amounts on the label, and ensuring safety. Ensure the NAD supplement lists all ingredients on the label, including quantity.
Dosage
When you buy a NAD supplement, make sure you know how much to take and how to use it safely. Check the label for the recommended dose and how to take it. Also, don’t take more than you need or use an expired supplement—you want to get the best results without any risks.
Cost
NAD supplements can vary in price, so it’s a good idea to compare different options and see which one fits your budget. That being said, don’t compromise on quality just to save a few bucks. Look for reputable brands and high-quality ingredients that deliver the benefits you want.
Potency
It’s essential to consider the potency of your NAD supplement to ensure you are getting enough of the active ingredient. The most potent formulas are generally higher priced but offer great value when considering their potency levels and doses per serving. In any case, you should always follow the dosage instructions on the label and avoid taking too much for your safety.
Absorption rate
How fast your body can take in a NAD supplement is an important thing to think about before you buy one. Generally speaking, most quality supplements will have higher absorption rates since they contain higher-quality ingredients that your body can efficiently absorb and quickly metabolize. Good supplements also have vitamins and minerals that help with absorption and make sure you get the most out of the supplement.
Side effects
Before you buy any dietary supplement, you should always look for possible side effects associated with taking it. You should also be aware of any interactions with medications or other supplements that may cause unexpected side effects. For example, some people who take NAD supplements may experience nausea, headaches, dizziness, stomach problems, dehydration, and so on. That’s why you need to do your homework before you add a new supplement to your routine.
Health benefits
NAD supplements can offer various health benefits depending on your goals. They can boost your energy and protect your cells from damage caused by oxidative stress and inflammation. Beyond that, they also support healthy digestion and prevent age-related cognitive decline by improving your mitochondrial health and metabolism. This is because NAD supplements help your body use ATP molecules, which are the main source of energy for your cells, more effectively. Further, these supplements can even reduce depression symptoms and aspects of cognitive function like memory and focus.
Safety, certifications, and regulatory standards
You want to make sure that the supplement you buy has been tested and certified by reputable organizations or standards, including the NSF (National Sanitation Foundation) or the FDA’s CGMP (Current Good Manufacturing Practice). These certifications indicate that the product meets the standards for safety and effectiveness in terms of how it is made and what it claims to do. They also show that the product contains the active ingredients and benefits that it advertises.
People Also Asked
What are the benefits of taking an NAD supplement?
A NAD supplement is a dietary supplement designed to improve energy, focus, and metabolism. This natural product boosts your NAD+ levels, which are essential for cellular metabolism and longevity. It also aids in detoxification, supports healthy aging, and strengthens the mitochondria.
How do NAD supplements work?
NAD supplements contain ingredients that help increase your natural nicotinamide adenine dinucleotide (NAD+) levels, which are essential for your cells to make energy and stay healthy. NAD+ also improves your metabolism, helps reduce fatigue, and supports cognitive functioning.
How many NAD supplements should I take daily?
Generally, the recommended dosage for NAD supplements is one capsule every day with a meal. But don't forget to talk to your doctor first before you try any new supplements. This way, you can make sure they are safe and effective for you.
Does this supplement interact with any medications or supplements I'm taking?
The NAD supplement may interact with certain medications or supplements, including those used to treat hypertension, diabetes, or other medical conditions, such as anticoagulants or antidepressants. Remember, always consult your healthcare provider before beginning any new supplement regimen.
What other ingredients are in NAD supplements?
The primary ingredient in NAD supplements is nicotinamide riboside, which helps provide the critical building blocks of energy production in cells and helps maintain healthy levels of NAD+. Other ingredients include pyrroloquinoline quinone (PQQ), coenzyme Q10 (CoQ10), L-glycerophosphate di-potassium salt, vitamin B6 and B12, magnesium malate, vitamin C, selenium, hyaluronic acid, alpha lipoic acid, sodium borate decahydrate, and silica. These ingredients help support overall health and wellness by promoting cellular energy production and mitochondrial health.
How long does it usually take to see results from taking NAD supplements?
It typically takes two to three weeks of taking these supplements daily to achieve the desired results, like improved energy, focus, metabolism, and cognitive functioning. Results can also vary depending on individual factors such as age and your overall health status.
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