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The Best Immune Support Supplements to Stay Healthy in 2025
Written By Supplement Institute Review Team
Your immune system serves as your body’s first line of defense in helping you heal after an injury and expediting recovery after illness. While a well-rounded diet can help strengthen immunity, it can often be insufficient in our modern world where we are pummeled by sickness and germs regularly. This is where immune support supplements fortified with vitamins and minerals can aid in keeping your immune system in peak shape.
Given the sheer number of supplements on the market, researching the best immune supplements can feel overwhelming. To help you, we scoured the supplements out there and evaluated the best of the best based on ingredient quality, efficacy, brand reputation, and customer reviews. We found the FreshCap Ultimate Mushroom Complex to be a top contender due to its clean ingredients and bioavailability. Read on to learn more about FreshCap’s brand and four other top-rated options.
The Best Immune Support Supplements of 2025
FreshCap Ultimate Mushroom Complex
Best Overall
The FreshCap Ultimate Mushroom Complex stands out as the top immune support supplement that supplies whole food ingredients to boost immunity naturally. Each capsule contains a mix of six of the most widely researched mushroom species – Turkey Tail for immune support, Lion’s Mane for mental clarity, Reishi for vitality, Cordyceps for energy, Chaga for cell health, and Maitake for heart health. FreshCap used whole fruiting bodies that were thoroughly extracted for bio-active compounds so you can get the most benefit out of each ingredient.
FreshCap takes its product potency seriously. Each batch of capsules is third-party tested to guarantee optimal levels of active compounds with more than 29% beta-glucans – the components of mushrooms with immunity-boosting power. I prioritize looking for supplements with only natural ingredients and no added fillers – and FreshCap fits this need by including only whole fruiting bodies without any grain fillers. Each container holds 120 capsules, to last about two months with a two-capsule-per-day serving size. The clean ingredient list and overall wellness support make FreshCap’s Ultimate Mushroom Complex the best overall immune support supplement.
Key features/specs
| Contains 6 types of organic mushrooms | |
| Certified Organic by CCOF | |
| Non-GMO and Gluten-Free | |
| Vegan and Paleo-friendly | |
| Third-party tested | |
| 29% beta-glucans content | |
| $36 per 120 capsule count per bottle | |
| Free from grain and filler additives |
Secret Element Citrus Bergamot Supplement
All-Natural Choice
The Secret Element Citrus Bergamot Supplement offers a natural approach to heart wellness and aging support. It contains 1000 mg of pure bergamot extract, standardized to a 40% polyphenol profile, and is designed to help maintain healthy cholesterol, triglyceride, and lipid levels. The supplement also supports heart function and stimulates cell energy production, which can be beneficial for healthy aging. With 2x the bioavailability of bergamot powders, this supplement maximizes absorption and effectiveness, making it a clean and potent addition to your wellness routine.
AloeCure Organic Aloe Vera Capsules
Best Digestion
AloeCure Aloe Vera Capsules rely on USDA-certified organic aloe vera to support gut health, digestion, and healthy immune function. This is a great option for anyone looking to boost immune health while improving digestion. AloeCure capsules contain some of the highest levels of Acemannan, a natural polysaccharide that helps support your immune system. Taking one capsule daily can also help soothe your stomach to promote healthy digestion.
To maximize product freshness and potency, all of their products are created within 12 hours of harvest. AloeCure also provides full product traceability so you can find exactly where the ingredients in your supplements are sourced from. Ingredient traceability is a big priority for me, as I want to be able to confirm that I’m not taking in any hidden ingredients. Their capsules are free of artificial flavors and preservatives, GMOs, gluten, and soy. AloeCure really values high-quality natural ingredients, making them a great immune support option.
Key features/specs
| Organic USDA-approved aloe vera |
Daiwa PeakImmune4 Immune Support Supplements
Most Rejuvenating
Daiwa PeakImmune4 Immune Support Supplements are formulated to boost your body’s natural defenses, making it easier to stay healthy year-round. These supplements contain a blend of natural ingredients, including arabinoxylane, which is known to support immune function and enhance the body’s ability to fend off infections.
Designed for everyday use, PeakImmune4 is ideal for those looking to strengthen their immune system and promote overall wellness. The easy-to-swallow capsules fit seamlessly into your daily routine, helping you stay active and healthy, no matter the season.
Nutricost Echinacea & Goldenseal Root
Best for Cold and Flu Prevention
Nutricost Echinacea & Goldenseal Root Supplement contains 250mg of Echinacea extract and 250mg of Goldenseal root in each capsule to boost your immunity and keep you healthy. Echinacea has been used for more than 400 years to help treat the ill and heal infections and wounds. In modern society, echinacea treats colds and flu by reducing associated symptoms such as sore throat, cough, and fever. Goldenseal root is a natural antibiotic that works with echinacea to strengthen the immune system.
Echinacea and goldenseal root are combined in an easy-to-swallow capsule, making it easy to add to your daily routine. Each container provides great value with 240 capsules to last about six months. With Nutricost’s commitment to quality, you can be confident that each capsule delivers the promised strength and purity. Their supplements are third-party tested, non-GMO, and gluten-free. Nutricost Echinacea & Goldenseal Root is a great option for those seeking a reliable health supplement to guard against cold and flu.
Key features/specs
| Contains Echinacea & Goldenseal Root | |
| Pack includes 240 veggie capsules | |
| Single serving comprises one capsule | |
| Suitable for vegetarians | |
| Free from gluten and GMOs | |
| Produced in a GMP Compliant facility | |
| FDA-registered production facility | |
| $15 for 240 servings |
Tru Niagen Immune Support Supplement
Best for Aging
The Tru Niagen Immune Support Supplement builds your defense against common health threats, actively bolstering your immune system. By combining Vitamin C from fermentation, vegan Vitamin D3 (2000 IU), Zinc, Theracurmin, and Niagen, this supplement supports your changing immune system as you age. These ingredients work together for full-body health starting at the cellular level. Taking Tru Niagen’s Immune Support supplement can help actively fuel your immune system to reinforce your body’s natural defenses. The Niagen added into each capsule can help increase NAD+ in your system by 40-50%, which is vital to your immune cell’s healthy function. Because of the high-quality ingredients, this is a pricier supplement at $34 for 30 capsules. Their formula is backed by over fifty years of science, with numerous scientific studies to validate the supplement’s effectiveness. Their wealth of research makes it seem like a trustworthy supplement to add to your daily routine.
Key features/specs
| Designed for age-related immune health | |
| Created by an award-winning company | |
| Contains patented supernutrient, Niagen | |
| Increases vital compound NAD+ levels | |
| Includes vitamins D, C, and zinc | |
| Contains highly absorbable Theracurmin | |
| Shelf-stable for 24 months post-manufacturing | |
| $34 for 30 servings |
Lunakai Vitamin E Gummies
Best Non-Pill Form
Lunakai’s Vitamin E Gummies provide a unique option to the traditional capsule-style immune supplements as an easy-to-chew, tasty passionfruit gummy. Each serving contains 250mg of Natural Vitamin E and 50 mg of Vitamin C to provide antioxidants that help with comprehensive immune support. This is also a great supplement to take after sun exposure to support healthy eyes and skin. Each gummy is crafted with non-GMO, vegan ingredients and only 3g of natural and organic sugars per serving.
Lunakai provides great value for high-quality ingredients at only $21 for a 60-count bottle. They also enforce a 100% Happiness Guarantee to ensure you not only love the taste of your supplements, but they also work to your liking. I always take it as a plus when companies offer satisfaction guarantees because it shows the company’s confidence in the quality of their product.
Key features/specs
| Vitamin E gummy supplement | |
| Non-GMO, Gelatin, Soy, and Corn Free | |
| 250 mg of Natural Vitamin E and 50 mg of Vitamin C per serving | |
| Kosher, Vegan, and Gluten Free supplement | |
| Formulated with only 3g of natural, organic sugars | |
| Developed and made in the USA | |
| Produced in a certified facility | |
| $21 for a 60-count bottle |
Buying Guide: Choosing an Immune Support Supplement
Nobody likes being sick – having to stay in bed all day and not being able to work or participate in the activities you love most while feeling absolutely awful. In our busy lives, it’s so important to maintain a robust immune system to fend off sickness and keep our health in check. Immune support supplements can help strengthen your immunity to keep you in peak health, even during cold and flu season. But with numerous options in the market, how do you choose the best immune support supplement? This guide helps you navigate some important factors to consider.
Quality of Ingredients
Always check the quality of ingredients when shopping for a new immune support supplement. You want to be mindful of anything you put in your body; try to prioritize real, organic, and non-GMO ingredients. Avoid supplements full of artificial additives, preservatives, and colorants. This information should be clear on the supplement’s label or the company website. Look for supplements with Vitamin C, Echinacea, Elderberry, Zinc, and Probiotics, which are well-known for boosting immunity.
Form of Supplement
Immune support supplements come in various forms, such as capsules, tablets, liquids, and powders. Capsules and tablets are portable and easier to use, while liquids and powders can be mixed into food or drinks for those who struggle with swallowing pills. Your lifestyle, personal preferences, and ease of use should guide you in selecting the form that suits you best.
Bioavailability
Bioavailability refers to the degree and rate at which your body absorbs a supplement. A supplement with high bioavailability ensures your body maximizes the nutrients, leading to improved immune function. Factors that affect bioavailability include the form of the supplement, the presence of other nutrients, and individual metabolic differences. Look for supplements that offer enhanced bioavailability – a feature often highlighted on the product packaging or description.
Brand Reputation
Brand reputation tells a lot about the trustworthiness of a supplement you may be researching. Brands with a strong reputation often deliver high-quality products and exhibit transparency in their manufacturing processes. They’re also more likely to provide detailed information about their products, including ingredients, potential side effects, and recommendations for use. Online reviews provide an honest snapshot of a brand’s reputation to help you make an informed choice.
Value for Money
While it’s essential not to compromise quality over cost, it’s also key to ensure you’re getting value for your money. Compare different immune support supplements based on the number of servings, ingredient quality, and overall effectiveness. A supplement might be pricier, but if it packs a higher concentration of immune-boosting ingredients and lasts longer, it may offer better value.
Third-Party Testing
Third-party testing is your assurance of safety and quality when researching a supplement you’ve never used before. Supplements tested by independent labs provide an unbiased verification of the product’s quality, potency, and purity. These tests also verify that what’s on the label is what’s in the bottle. Look for supplements carrying a seal from reputable third-party testers like NSF International, USP, or ConsumerLab.
Immune Support Supplement FAQs
Can anyone take immune support supplements?
While immune support supplements are generally safe for most people, you should always consult a healthcare professional before starting any new supplement regimen.
Are there any side effects of taking immune support supplements?
While most people do not experience any side effects, some may experience mild effects such as stomach upset, nausea, or diarrhea. If you experience severe or persistent side effects, stop taking the supplement and consult a healthcare professional.
How long does it take for immune support supplements to work?
The time it takes for immune support supplements to work can vary depending on the individual and the specific product. However, supplements are typically meant to be taken over a period of time to support overall immune health rather than providing immediate results.
Can I take immune support supplements with other medications?
It is always recommended to consult with a healthcare professional before starting any new supplement regimen, especially if you currently take any other medications. Some supplements can interact with certain medications, potentially reducing their effectiveness or causing side effects.
Are immune support supplements a substitute for a healthy diet and lifestyle?
No, immune support supplements are not a substitute for a healthy diet and lifestyle. They are meant to supplement, not replace, a balanced diet, regular exercise, adequate sleep, and other healthy lifestyle habits.
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