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The Best Aging Supplements to Age Gracefully in 2025
Written By Supplement Institute Review Team
As our generation invests more in beauty, skincare, and wellness products, companies aim to meet our needs by creating a new niche of wellness products. In addition to your standard multi-vitamin, there’s now an entire supplement market to support our changing bodies throughout the years, promoting healthy aging. Scientists spend years rigorously researching which vitamins and minerals support longevity, vitality, and overall wellness as we age.
We assessed numerous aging supplements based on brand reputation, ingredient list, and user reviews to see which brands produce the most effective supplements. Sitting at the top of our list is the Timeline Mitopure Urolithin A Againg Supplement due to its clean formula and proven support for muscle strength, endurance and longevity. If Timeline’s formula doesn’t suit your needs, read on to learn more about the other top-rated supplements on our list to help you age gradefully!
Detailing the Top Aging Supplements of 2025
Timeline Aging Supplement
Best Overall
Timeline’s Mitopure Urolithin A is backed by over 15 years of research to develop a postbiotic formula that revolutionizes cellular aging. This supplement is the first of its kind, containing a highly pure form of Urolithin A to trigger a cellular renewal process that increases strength and improves endurance. A 500mg dose daily has been shown to increase muscular strength by up to 12% and improve muscular endurance by up to 17% to combat muscle degeneration associated with aging.
This supplement not only helps with increasing muscular strength and endurance but also promotes increased energy. It directly targets mitochondria (the powerhouse of cells) to enhance energy production and overall cellular function. Timeline guarantees a clinically tested supplement free of both GMOs and gluten to give you the highest quality product. Do keep in mind, however, that this supplement has a high price point of $57 for fourteen servings. Despite the higher cost, their patented technology backed by years of science and clinical trials makes Timeline’s Mitopure Urolithin A the best aging supplement we researched.
Key features/specs
| Powered by Mitopure technology | |
| Made in the USA with globally sourced ingredients | |
| First-of-its-kind Mitoceutical supplement | |
| Formulated by physicians for age-related issues | |
| Clinically proven to increase muscle strength by 12% | |
| Clinically proven to increase muscle endurance by 17% | |
| Acts as an alternative to NAD+, CoQ10, PQQ and resveratrol | |
| $57 for 14 servings |
Naturelo Aging Supplement
Best for Women 50+
Naturelo created a supplement specifically for women 50+ to help combat the toll aging can take on the body. Each capsule contains 23 essential vitamins and minerals sourced from nature to support healthy aging, including Vitamin D3 from lichen, Vitamin E from sunflower, plant Calcium, Magnesium from marine algae, and Idoine from kelp. These vitamins become increasingly important with age. For example, calcium keeps bones strong to prevent fractures and osteoporosis in older women.
Naturelo also included B vitamins and chelated minerals that support absorption and bioavailability to get the most out of each capsule. This supplement was formulated to support heart, brain, eye, and immune health through organic whole foods to keep you in peak health. Naturelo refuses to use preservatives, gelatin, coloring, or flavoring; each product is produced in a GMP-compliant facility to guarantee a high-quality product. These capsules are also allergen-friendly without soy, gluten, preservatives, GMOs, or dairy. Each container contains 120 capsules to supply you for four months with their recommended 1-a-day serving size.
Key features/specs
| Contains 23 essential vitamins and minerals | |
| Formulated with organic fruits and vegetables | |
| Uses plant-based vitamins such as Vitamin D3 from lichen | |
| Incorporates activated B Vitamins and chelated minerals | |
| Supports healthy aging with natural energy boosters | |
| Free from preservatives, gelatin, coloring, or flavoring | |
| Vegan, Non-GMO, Soy Free, and Gluten Free | |
| $35 for a 4-month supply |
Nature Made Aging Supplement
Best for Skin Health
As we age those dreaded wrinkles start to show and our skin loses the elasticity it once had in our youth. NatureMade’s Collagen gummies combine hydrolyzed collagen with Vitamin C, Zinc, Biotin, and Vitamin E to support healthy skin as you age. Collagen has been scientifically linked to improved skin moisture, elasticity, and hydration, and regular supplementation reduces wrinkling and roughness of the skin that comes with age.
These supplements come in a gummy form; a huge benefit for those who hate swallowing pills. Its refreshing lemon flavor makes taking supplements feel more like a treat than a chore. The recommended serving size is 1 gummy daily, providing a two-month supply in each container with 60 gummies. NatureMade touts itself as the Number 1 Pharmacist Recommended Vitamin & Supplement brand with over 50 years of experience in the industry. I look for supplement companies backed by professionals in the field, as it lends to their credibility in creating safe, effective supplements. Each gummy is produced without artificial flavors, synthetic dyes, high fructose corn syrup, artificial sweeteners, or gluten so you get only what you need.
Key features/specs
| Contains hydrolyzed bovine collagen | |
| Combined with Vitamin C, Vitamin E, Zinc, and Biotin | |
| Delicious lemon gummy | |
| Made with fruit pectin | |
| A serving size is 1 gummy per day | |
| One 60-gummy container is $16 | |
| No artificial flavors, synthetic dyes, high fructose corn syrup, artificial sweeteners, or gluten |
CITRACAL Aging Supplement
Best for Bone Health
The CITRACAL Calcium Supplement Gummies supplies 500mg of calcium and 35 mcg of Vitamin D3 per serving to support bone health as your body changes with age. Calcium is a common mineral found in food sources, but many of us don’t get enough from food alone. As you age, your bone density can decline without proper calcium consumption leading to fractures and breaks. Calcium works with Vitamin D3 to strengthen your bones, allowing you to lead a healthier and more active life without the risk of injury.
As a bonus this supplement comes as a gummy, making it a great option for those who struggle with swallowing pills. Its fun raspberry flavor makes me look forward to taking my supplements in the morning, rather than dreading it. Just two gummies twice a day can potentially help prevent osteoporosis by increasing your daily dose of calcium. This supplement even has the backing of healthcare professionals as the number one doctor and pharmacist-recommended calcium brand.
Key features/specs
| Contains 500mg Calcium per serving | |
| Includes 25 mcg Vitamin D3 | |
| Raspberry flavored gummies | |
| A serving is 2 gummies twice a day | |
| Ideal for non-pill takers | |
| Recommended by health professionals | |
| $40 for 2 packs of 60 gummies |
Garden of Life Aging Supplement
Best for Women’s Digestive Support
Garden of Life’s Once Daily Women’s Probiotic was formulated specifically to provide digestive and immune support for women. 16 strains of diverse probiotics combined with a whole food prebiotic fiber blend promotes the growth of good bacteria and keeps your digestive system working in peak shape. As we age, our risk of digestive disorders increases making it increasingly important to stay proactive about our digestive health.
Garden of Life’s doctor-formulated probiotic combines scientifically researched strains such as L. reuteri and L. fermentum to create good bacteria and balance pH levels for a woman’s overall health. Their doctors have run through many clinical trials and studies to ensure their products are both high quality and effective. Each tablet can be taken orally as is, or it can be opened and mixed into your favorite cold beverage to avoid swallowing pills. Dr. Perlmutter, the doctor who formulated Garden of Life’s Once Daily Women’s Probiotic, designed a third-party certified, non-GMO, gluten-free supplement to provide only the highest quality nutritional support for women’s health.
Key features/specs
| Formulated by Dr. David Perlmutter, MD | |
| Contains 50 Billion CFU of 16 probiotic strains | |
| Includes L. reuteri and L. fermentum strains | |
| Enhanced with whole food prebiotic fiber blend | |
| Available in once-daily vegetarian capsules | |
| Capsule contents can be mixed with water or juice | |
| Certified Non-GMO, Gluten-Free and Carbon Neutral | |
| $31 for 30 capsules |
7 Factors to Consider When Choosing an Aging Supplement
Aging is a natural process that as human beings we all experience. Yet the process of aging can be frustrating as our bodies start to change with time. Most want to age gracefully, preserving our youthful vigor and appearance for as long as possible. Aging supplements can be a useful tool to combat common signs of aging both internally and externally. They can help slow down signs of aging by keeping our internal systems running efficiently while diminishing external signs of aging, such as wrinkles and fine lines. With an array of options on the market, it can feel quite challenging to choose the best aging supplement for your needs. We researched the top factors that influence a high-quality aging supplement to make your research process a little easier.
Ingredients
Look at the ingredient list as the first step in researching a new supplement. Common ingredients often found in aging supplements include collagen, Vitamin D, Vitamin B6, Vitamin B12, Vitamin C, and Vitamin E. Our natural supplies of these vitamins and minerals start to decline as we age, making them common in supplements formulated for aging. Opt for supplements containing natural ingredients to ensure only the highest quality ingredients go into your body.
Dosage
The dosage of supplements can vary from brand to brand, so it’s important to look at the ingredient list when researching a new option. Too much of a good thing can be harmful, so always consider the recommended daily intake of vitamins and minerals compared to what’s listed on the bottle. Some supplements require a single daily dose, while others require several servings throughout the day. Ensure the dosage of the brand you’re considering aligns well with your daily routine for easy integration and maximum benefits.
Brand Reputation
Brand reputation can play a large factor in determining which company to purchase from. Trustworthy brands with a history of producing high-quality supplements ensure their products are safe and effective. Research how transparent the brand is by investigating ingredients, reading about manufacturing processes, and skimming through customer reviews. A reliable brand will always be open about such details.
Third-Party Testing
Having a supplement undergo third-party testing ensures its safety, purity, and potency. Third-party labs are independent entities that verify the quality of products without any risk of bias. Supplements that have undergone third-party testing indicate that the company is confident in its product’s quality and safety.
Price
While it’s easy to assume that the most expensive supplement is the best, that’s not always the case. A high price tag doesn’t necessarily equate to high quality. Compare different brands and their prices. Look at the per-serving cost to determine which supplement offers the best value for money.
User Reviews
User reviews give real-time feedback from folks with actual experience using the product. They provide real insights into how effective the supplement is and any potential side effects. Look for consistent positive reviews from users. But remember, individual results can vary so take away common themes from the reviews.
Contraindications
Some aging supplements may interact with certain medications or health conditions. Always check if the supplement has any contraindications. If you’re on medication, have a chronic illness, or are pregnant, it’s advisable to consult with a healthcare professional before starting any new supplement.
Aging Supplement FAQs
What is an aging supplement?
An aging supplement is a product designed to combat the signs of aging and promote overall health. They often contain a blend of vitamins, minerals, antioxidants, and other nutrients essential for maintaining the body's youthful function.
How do I use an aging supplement?
Most aging supplements come in pill or capsule form. You should follow the dosage instructions given by the manufacturer or your healthcare provider, which is often one or two pills a day with a meal.
Are there any side effects of using aging supplements?
Side effects vary depending on the specific supplement and the individual taking it. Some people may experience minor digestive discomfort or allergic reactions. It's always best to consult your healthcare provider before starting any new supplement regimen.
Can I take an aging supplement with my current medication?
It's crucial to consult with your healthcare provider before starting any new supplement regimen, especially if you're currently taking other medication. Some supplements can interact with certain types of medication, possibly leading to serious health complications.
Are all aging supplements the same?
No, not all aging supplements are the same. They can vary greatly in terms of their ingredients, effects, and quality. Do your research and choose a product that fits your specific needs and health goals.
How should I store my aging supplements?
Most aging supplements should be stored in a cool, dry place away from direct sunlight. Always check the bottle for specific storage instructions to ensure your supplements stay as effective as possible.
Do aging supplements replace a healthy diet and exercise?'
No, aging supplements are not a replacement for a balanced diet and regular exercise. They are meant to supplement a healthy lifestyle, not replace it. For best results, use them in conjunction with a balanced diet and regular physical activity.
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